| 1. | Choose all drugs that should be taken on an empty stomach |
| A. |
| B. |
| C. |
| D. |
| E. |
| 2. | Which drugs are hard on the liver? |
| A. |
| B. |
| C. |
| D. |
| 3. | Which anthelmintic is Chewable? |
| A. |
| B. |
| C. |
| D. |
| 4. | Do NOT use these if Pregnant, can cause adverse effects (may be more than one correct answer) |
| A. |
| B. |
| C. |
| D. |
| 5. | Which drug group inhibits folic acid synthesis? (therefor may cause birth defects) |
| A. |
| B. |
| C. |
| D. |
| 6. | This drug interacts with Diuretics and Neuromuscular Blockers |
| A. |
| B. |
| C. |
| D. |
| 7. | Tetracyclines decrease the effect of this drug; this drug decreases the effect of aminoglycosides |
| A. |
| B. |
| C. |
| D. |
| 8. | Not for kids under 8 because it will stain their teeth |
| A. |
| B. |
| C. |
| D. |
| 9. | These are metabolized in the liver and excreted in urine and feces |
| A. |
| B. |
| C. |
| D. |
| 10. | This may have cross sensitivity with thiazide diuretics and sulfonylureas |
| A. |
| B. |
| C. |
| D. |
| 11. | This drug is nicknamed HENPEcK |
| A. |
| B. |
| C. |
| D. |
| 12. | Treats Oropharyngeal Candidiasis, Vaginal preps and Tineas |
| A. |
| B. |
| C. |
| D. |
| 13. | Newer class, less toxic than Amphotericin B but also less effective |
| A. |
| B. |
| C. |
| D. |
| 14. | Topical, minimum of 6 months daily use, treatment of Onychomycosis (nail fungus) |
| A. |
| B. |
| C. |
| D. |
| 15. | Don’t use if pt has kidney disease, can go into kidney failure |
| A. |
| B. |
| C. |
| D. |
| 16. | This drug prevents shedding of viral protein coat and increases dry mouth with anticholergenic agents |
| A. |
| B. |
| C. |
| D. |
| 17. | Prevents HIV from transfering to an unborn child |
| A. |
| B. |
| C. |
| D. |
| 18. | Treats Herpes 1 & 2, Severe Genital Herpes, Chicken Pox and Shingles |
| A. |
| B. |
| C. |
| D. |
| 19. | Most commonly diagnosed parasite in the US, contracted through food or water |
| A. |
| B. |
| C. |
| D. |
| 20. | Good alternative to Penicillin if allergic |
| A. |
| B. |
| C. |
| D. |
| 1. | Name, in alphabetical order, the 4 drugs that fit the following criteria:Class: AntimetabolitesSublcass: Nucleotide AnalogsAlphabetize drugs with numbers by the first letter after the number and a hyphen, i.e. 8-Drug. |
| 2. | This drug is an Alkylating Agent that is less toxic than cisplatin, but also less active.Answer: Subclass, Drug |
| 3. | Of the following Antimetabolites, which is/are Folate Antagonists? |
| A. |
| B. |
| C. |
| D. |
| E. |
| 4. | What chemo agent’s DLT includes ALL of the following:NephrotoxicityNeurotoxicityOtotoxicityMinimal marrow toxicityAnswer: Class, Subclass, Drug |
| 5. | Name the 3 subclasses of alkylating agents. |
| A. |
| B. |
| C. |
| D. |
| E. |
| 6. | Resistance to which of the following drugs is due to cellular acquisition of Aldehyde Oxidase? |
| A. |
| B. |
| C. |
| D. |
| E. |
| 7. | Following treatment with Methotrexate, this drug is used to “rescue” cells. (Class, Drug) |
| 8. | Patients with a deficiency in Dihydrothymidine Dehydrogenase can have a fatal interaction with which of the following drugs: |
| A. |
| B. |
| C. |
| D. |
| E. |
| 9. | Which of the following is commonly used to treat pancreatic islet cell carcinoma and pancreatic adenocarcinoma due to its enhanced uptake by pancreatic beta cells? (Note it is also used to treat colorectal cancer) |
| A. |
| B. |
| C. |
| D. |
| E. |
| 10. | 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits Thymidylate Synthase. What drug is an analog of 5-FU?Answer: Drug |
| 11. | A patient is being treated for Hodgekins disease. More than one of the following drugs are commonly used to treat patients with this condition. Which ones are they? |
| A. |
| B. |
| C. |
| D. |
| E. |
| 12. | Which of the following are Antimetabolites? (Select all that apply) |
| A. |
| B. |
| C. |
| D. |
| E. |
| 13. | This alkylator is localized to the liver and has an increased half-life. It’s DLT includes bone marrow suppression.ADME: Dose IVUsed to treat Melanoma, Hodgkin’s DiseaseAnswer: Drug |
| 14. | The mechanism of action of this drug is as follows:Loses Cl-; forms carbonium ion that attacks nucleophiles.It has a half life of less than 10 minutes following IV injection.Answer: Class, Subclass, Drug |
| 15. | Name the 3 Nitrosureas in alphabetical order. (Answer: Drug, Drug, Drug) |
| 16. | A patient is recieving ongoing treatment for gliobastoma. Select all of the following that could be used to treat this tumor. |
| A. |
| B. |
| C. |
| D. |
| E. |
| 17. | This Platinum Compound lacks cross-resistance with the other two platinum compounds. |
| 18. | There is a risk of secondary neoplasia, bone marrow suppression, as well as birth defects associated with which chemotherapy drug that is commonly used to treat chronic and acute myelogenous leukemia (CML and AML): |
| A. |
| B. |
| C. |
| D. |
| E. |
| 19. | This drug is a bifunctional agent that is used to treat chronic lymphocytic leukemia and non-Hodgkins lymphoma. (Answer as Subclass, Drug) |
| 20. | This chemo drug is commonly used to treat small-cell and non small-cell lung cancers as well as ovarian cancer. |
| 21. | This drug traps Acrolein and protects from bladder toxicities but has NO anticancer activity.(Answer: Class, Drug) |
| 22. | Which drug has the following characteristics:Mechanism: Inhibits DNA polymerase alpha causing termination of DNA synthesisResistance: Cytidine deaminase detoxificationToxicity: Potent myelosuppressive, neurotoxicity with renal impairmentADME: Sensitive to dosing scheduleOther: Combo therapy for leukemias |
| A. |
| B. |
| C. |
| D. |
| E. |
| 23. | Which of the following is administered orally due to the fact that it is readily absorbed by the GI tract? |
| A. |
| B. |
| C. |
| D. |
| E. |
| 24. | What drug fits the following criteria:Lacks cross-resistance with other alkylating agents.Toxicity: Secondary leukemia or lung cancerDLT: PneumonitisADME: Oral, non-cell cycle phase specificAnswer: Drug |
| 25. | This alkylating agent has delayed-type bone marrow suppression. Answer as follows: Subclass, Drug. |
| 26. | This drug is activated by HGPRTase, thus resistance is acquired via decreased activity of HGPRTase. |
| A. |
| B. |
| C. |
| D. |
| E. |
| 27. | The following Alkylating Agent has a high oil-to-water partition coefficient, thus bone marrow suppression from it may persist due to storage in adipose tissue and liver. Answer: Subclass, Drug |
| 28. | This Nitrogen Mustard will not cross the Blood Brain Barrier (BBB). |
| 29. | Which of the following drugs are used to treat glioblastomas? |
| A. |
| B. |
| C. |
| D. |
| E. |
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